|
Raúl Rabadán received a PhD in Theoretical Physics in 2001 under the supervision of Luis Ibanez at the Universidad Autonoma de Madrid, in Madrid, Spain〔(Raúl Rabadan Gripe porcina ) Raúl Rabadan es profesor de biomedicina y biología en la Universidad de Columbia de Nueva York. Desde la distancia ha charlado con los oyentes sobre sus dudas en la posible pandemia de la gripe porcina que tiene atemorizada a tanta gente〕 and went on to conduct research in that field for a further five years at the European Laboratory for Particle Physics (CERN) in Switzerland and at the Institute for Advanced Study (IAS) in Princeton. In 2006 he joined the Simons Center for Systems Biology program at IAS, as a Martin A. and Helen Chooljian Member. In 2008, Dr. Rabadan moved to Columbia University as an Assistant Professor, with a joint appointment in the Department of Systems Biology and the Department of Biomedical Informatics. At Columbia, he has put together a highly interdisciplinary lab with researchers from the fields of mathematics, physics, computer science, engineering, and medicine, with the common goal of solving pressing biomedical problems through quantitative computational models. ==Career== Dr. Rabadan is an expert on string theory phenomenology, specifically the physics of intersecting D-brane configurations. In his more recent research in physics he has studied the information paradox of black holes in the context of the Anti-de Sitter/Conformal Field Theory duality, and has proposed several experiments to search for axions. In the last 10 years he has focused his research program on theoretical and computational problems in biology. Dr. Rabadan scientific interests lie in modeling and understanding the dynamics of biological systems through the lens of genomics. He has focused his research on the evolution of two of such biological systems: cancer and infectious diseases. In particular, he has been working in the identification of driver mechanisms of evolutionary processes, characterize key process dynamics and elucidate epistasic interactions. Dr. Rabadan is interested in understanding the evolution of infectious agents through the analysis of their genome, in particular influenza viruses including elucidating the origin of the influenza A virus subtype H1N1.〔Trifonov, V., Khiabanian, H., Greenbaum, B. & Rabadan, R. The origin of the recent swine influenza A(H1N1) virus infecting humans. Euro Surveill 14 (2009).〕〔Trifonov, V., Khiabanian, H. & Rabadan, R. Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus. N Engl J Med 361, 115-119, doi:10.1056/NEJMp0904572 (2009).〕 Dr. Rabadan's work in cancer genetics has led to the identification of driver alterations in hairy cell leukemia,〔Tiacci, E. et al. BRAF mutations in hairy-cell leukemia. New Engl J Med 364, 2305-2315, doi:10.1056/NEJMoa1014209 (2011).〕 diffuse large B-cell lymphoma,〔Pasqualucci, L. et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471, 189-195, doi:10.1038/nature09730 (2011).〕〔Pasqualucci, L. et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 43, 830-837, doi:10.1038/ng.892 (2011).〕 T-cell acute lymphoblastic leukemia,〔Van Vlierberghe, P. et al. PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet 42, 338-342, doi:10.1038/ng.542 (2010).〕〔Tzoneva, G. et al. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med 19, 368-371, doi:10.1038/nm.3078 (2013).〕 chronic lymphocytic leukemia,〔Rossi, D. et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119, 521-529, doi:10.1182/blood-2011-09-379966 (2012).〕〔Rossi, D. et al. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 121, 1403-1412, doi:10.1182/blood-2012-09-458265 (2013).〕〔Rossi, D. et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 118, 6904-6908, doi:10.1182/blood-2011-08-373159 (2011).〕 splenic marginal zone lymphoma〔Rossi, D. et al. The coding genome of splenic marginal zone lymphoma:activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med 209, 1537-1551, doi:10.1084/jem.20120904 (2012).〕 and glioblastoma multiforme;〔Singh, D. et al. Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma. Science, doi:10.1126/science.1220834 (2012).〕〔Singh, D. et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235, doi:10.1126/science.1220834 (2012).〕 and to the identification of recurrent alterations, which lead to therapy resistance, using longitudinal data in T-cell acute lymphoblastic leukemia7. Recently, he has been working on the application of topological data analysis to large scale genomic data.〔Chan, J. M., Carlsson, G. & Rabadan, R. Topology of viral evolution. Proc Natl Acad Sci U S A 110, 18566-18571, doi:10.1073/pnas.1313480110 (2013).〕〔K. Emmett, R. R. Characterizing Scales of Genetic Recombination and Antibiotic Resistance in Pathogenic Bacteria Using Topological Data Analysis. Lecture Notes in Computer Science (LNCS) (2014).〕 Dr. Rabadan’s scientific work has led to more than 100 peer-reviewed scientific publications, including in high impact factor journals (New England Journal of Medicine, Nature, Science, Nature Genetics, Nature Medicine, Cell, among others). Several of his results have been featured by the international press, including CNN, the New York Times, the Wall Street Journal, the Associated Press, Reuters International, and The Economist. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Raúl Rabadan」の詳細全文を読む スポンサード リンク
|